A systematic review on clinical outcomes of human amniotic membrane preparations in the management of venous leg ulcers

Introduction: Venous leg ulcers are the commonest type of chronic lower worldwide. It impacts patient’s quality life significantly. Our objective was to assess current evidence onusing human amniotic membranes (HAM) in venous ulcer management. Methods: Google Scholar, PubMed, and Cochrane library were utilized search following terms (MeSH PubMed) abstract field or title, “Amnion” OR “Placenta” AND “Varicose “OR “Stasis ulcer” “Chronic ulceration” studies published until 1st March 2022. We used standard methods articles. The articles thus included cohort (both retrospective prospective) randomized control trials. Results: When above criteria search, 12, 8, 15,6, 4 citations found MEDLINE, Library, Embase, Web Science respectively. 15 nonduplicate screened with inclusion exclusion criteria, we selected 7 for this review. However, membrane preparations these not uniform. All controlled trials (n=3) have concluded that there is an improvement healed percentage at end study interventional group when compared group, which statistically significant (p<0.05%). had 60% groups One prospective showed recurrence rate less than 30% a 3-year follow-up examination. couldn't perform meta-analysis due heterogeneity. Conclusion: Current scientific indicates can be promoting forms adjunctive traditional treatment as second-line therapy.